New evidence for an inflammatory component in diarrhea caused by selected new, live attenuated cholera vaccines and by El Tor and Q139 Vibrio cholerae.
نویسندگان
چکیده
Using a lactoferrin latex agglutination assay, we have compared the inflammatory responses to a cholera vaccine candidate, CVD 110, in which all known toxin genes have been deleted or mutated yet still produced significant diarrhea, with a less reactive vaccine strain and wild-type El Tor and 0139 Vibrio cholerae strains. Data suggest that diarrhea due to attenuated and wild-type El Tor V. cholerae, and to a lesser extent 0139 V. cholerae, involves an inflammatory response. Further study is required to further elucidate the mechanism of the process(es) involved.
منابع مشابه
Determination of ctxAB expression in Vibrio cholerae Classical and El Tor strains using Real-Time PCR
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ورودعنوان ژورنال:
- Infection and immunity
دوره 64 6 شماره
صفحات -
تاریخ انتشار 1996